Owing to their persistence and non-degradability, industrial effluents laden with high concentrations of ammonia and heavy metals are considered a major problem in densely populated developing countries. This study was displayed during spring 2018 to winter 2019 for elucidating the pollution load that is administrated through El-Delta for fertilizers and chemical industries (EFCI) company effluent to the drainage system. Parameters included temperature, pH, conductivity, total dissolved salts (TDS), biological oxygen demand (BOD), chemical oxygen demand (COD), dissolved oxygen (DO), total hardness, total alkalinity, chloride, NO₂-N, NO₃-N, NH₄-N, dissolved reactive phosphorus (DRP), total dissolved phosphorus (TDP), reactive silica and some of the heavy metals (Fe, Zn , Pb , Ni , Cd and Mn) were determined. Results demonstrated significant (P≤0.05) increments in water pH (9.84± 0.01), NH₄-N (187.76± 0.14 mg L^-1),Cu (0.439±0.002 mg L^-1) in the winter and TDP (0.76  mg L^-1) in summer. Toxicity test was carried out using the standard test alga Pseudokirchneriella subcapitata and in parallel Chlorella vulgaris and Scenedesmus dimorphus to assess the toxicity degree of wastewater on the test microalgae growth. Wastewater was highly toxic for Pseudokirchneriella subcapitata growth with EC₅₀ value 0.046 % (v/v), whereas the test microalgae Scenedesmus dimorphus and Chlorella vulgaris exhibited some tolerance to wastewater toxicity with EC₅₀ values 10.323 % and 18.411 %, respectively. Thus, these findings highlight the study area's deteriorating condition and new research opportunities that could be opened by the proposed treatment process, especially for the possible cultivation of Chlorella vulgaris and Scenedesmus dimorphus on such industrial effluent after pretreatment.