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165931

Mesoderm Signaling Pathways of Early Development in the Zebrafish Danio rerio

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Last updated: 01 Jan 2025

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Abstract

The zebrafish (Danio rerio) is an ideal fish model for molecular and genetic studies. It is relatively easy to keep in the aquarium and to obtain embryos. The ability to follow embryonic development using microscopic and molecular techniques facilitates the study of mesoderm development. Hence, this study was conducted to investigate the role of four transcription factors that include: bone morphogenetic protein (BMP), nodal, fibroblast growth factor (FGF) and sonic hedgehog (SHH) in mesoderm induction, using specific inhibitors (DM, SB431542, SU5402) and Cyclopamine, respectively. Each inhibitor perturbed mesoderm development and in situ hybridisation, using myl10 specific marker for muscles. Results showed a noticeable reduction in gene expression with each treatment, indicating a crucial role for all four transcription factors in mesoderm development.

DOI

10.21608/ejabf.2021.165931

Authors

First Name

Ilham

Last Name

J.J. Alshami

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Orcid

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First Name

Hussein

Last Name

A. Saud

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Volume

25

Article Issue

2

Related Issue

22958

Issue Date

2021-03-01

Receive Date

2021-04-23

Publish Date

2021-03-01

Page Start

601

Page End

614

Print ISSN

1110-6131

Online ISSN

2536-9814

Article File

EJABF_Volume 25_Issue 2_Pages 601-614.pdf

PDF . 724.7kB

Link

https://ejabf.journals.ekb.eg/article_165931.html

Detail API

https://ejabf.journals.ekb.eg/service?article_code=165931

Order

33

Type

Original Article

Type Code

103

Publication Type

Journal

Publication Title

Egyptian Journal of Aquatic Biology and Fisheries

Publication Link

https://ejabf.journals.ekb.eg/

MainTitle

Mesoderm Signaling Pathways of Early Development in the Zebrafish Danio rerio

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Type

Article

Created At

22 Jan 2023