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158608

Therapeutic Effect of Sepia pharaonis Ink Extract and Ellagic Acid on the Toxicity Induced by Cyclophosphamide in Male Albino Rats

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Last updated: 01 Jan 2025

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Abstract

The combination between anticancer drugs and natural products has great attention aiming at exploiting their efficiency and reducing systemic toxicity. Subsequently, the current study was constructed to evaluate the potential curative role of crude Sepia ink extract (SIE) and Ellagic acid (EA) against cyclophosphamide (CP) toxicity. Male albino rats were divided into five groups (n = 10). All groups except group I received CP. Group I served as a control group, group II received a single dose of CP (200 mg/kg, i.p.) and served as CP group, rats of group III received CP + SIE (200 mg/kg body weight), group IV received CP+ ‏ EA (60 mg/kg) and group V received CP + SIE (200 mg/kg body weight) + EA (60 mg/kg). Data showed that CP administration significantly decreased RBCs, WBCs, PLTs count, PCV%, and Hb content. Post administration of SIE and EA caused a significant elevation in the hematological values. Also, SIE and EA treated groups reduced the hepatic and renal toxicity induced by CP treatment, where liver and kidney functions (AST, ALT, ALP, creatinine, urea, and uric acid) significantly decrease. On the other hand, serum albumin and T. protein levels increased compared to CP-treated groups. The current results revealed that CP induced hematological alterations and various tissues injury. Natural products as SIE and EA eliminated the CP toxicity.

DOI

10.21608/ejabf.2021.158608

Keywords

cyclophosphamide, Sepia pharaonis, Sepia ink extract, Ellagic acid, hematological analysis, Liver functions

Authors

First Name

Naglaa

Last Name

R. A. Kasem

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Orcid

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First Name

Dalia

Last Name

S. Hamza

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Orcid

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First Name

Mona

Last Name

S. Azab

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Orcid

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First Name

Sherifa

Last Name

H. Ahmed

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Volume

25

Article Issue

2

Related Issue

22958

Issue Date

2021-03-01

Receive Date

2021-03-23

Publish Date

2021-03-01

Page Start

89

Page End

102

Print ISSN

1110-6131

Online ISSN

2536-9814

Article File

EJABF_Volume 25_Issue 2_Pages 89-102.pdf

PDF . 886.3kB

Link

https://ejabf.journals.ekb.eg/article_158608.html

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https://ejabf.journals.ekb.eg/service?article_code=158608

Order

7

Type

Original Article

Type Code

103

Publication Type

Journal

Publication Title

Egyptian Journal of Aquatic Biology and Fisheries

Publication Link

https://ejabf.journals.ekb.eg/

MainTitle

Therapeutic Effect of Sepia pharaonis Ink Extract and Ellagic Acid on the Toxicity Induced by Cyclophosphamide in Male Albino Rats

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Article

Created At

22 Jan 2023