The present work aimed to investigate the effect of Biofloc technology at different densities (60 &80 fish/m3) and feeding rates (2% & 3%) of Oreochromis niloticus vs control clear water groups on growth performance and protein utilization, then the estimation of economic evaluation on production scale (3000 m³) based on the output of the present work. A 20-week study was performed from June to October 2019. Triplicate four Biofloc groups vs four control once were used. All Biofloc groups had additional carbohydrates diets composed of molasses and rice brane (1:1) Circular 250 Liter tanks with 200 Liter were used. Results of growth and feed conversion ratio in the present study were used to estimate economic evaluation of production scale (Feddan composed of 3000 m3 net volume). Generally, Biofloc improved growth performance, protein utilization and achieved more estimated net income than clear water groups net income with 9/1 provide of water consumption.