The present investigation was carried out during summer 2016 to determine the possible bioactive components extracts with six solvents (Methanol, Methylene Chloride, EtOH, Ethyl Acetate, Acetone, and Chloroform) from soft coral, Sinularia maxima using GC-MS analysis. Sixty-four compounds were identified from the six extracts. The prevailing compounds in these extracts were Alloaromadendrene (8.8); Hexadecanoic acid, methyl ester (9.4); batilol (12.5); Dimethyl Sulfoxide (2.4); n-Hexadecanoic acid (9.6); Heneicosane (11.6); Octacosanol (12.5). The compounds produced by the studied soft corals possess antimicrobial activity against a number of Gram-positive and Gram-negative bacteria, fungi, and Cancer cell lines, in addition to other pharmaceutical activities.