Coastal sediments' quality may become impaired due to anthropogenic pressures, risking the well-being of humans and the ecosystem concerned. In this study, butyltin contamination in Egyptian Red Sea Coast's sediments was assessed for the first time, following the ten-year ban on antifouling paints' harmful organotin. We collected sediment samples from ten stations based on the proximity of anthropogenic activities. TBT, MBT, DBT, ƩBT, and TSn's concentrations were within the following ranges 7–220, 4.2–78, 14.7–339.8, 3.5–48.8 ng Sn g^-1, and 0.09–1.47µg Sn g^-1, respectively. The highest of butyltin concentrations were recorded in summer. TBT was the most abundant (52.79%–53.13%) while the averages of percentages of DBT were 18.45% and 19.33%, whereas MBT values were 27.88% and 28.42% in winter and summer, respectively. A significant positive correlation was found between butyltin derivatives and geochemical characteristics such as grain size of investigated sediments and organic matter. Contamination patterns of butyltin derivatives in the sediments of the area of study were TBT > MBT > DBT and most of the investigated samples had BDI values around one, which proves TBT has no recent input and degraded immensely. Meanwhile, a portion of 80% of the samples was established to be highly tributyltin contaminated.