A seasonal study was performed on 500 marine fishes (100 Engraulis encrasicolus, 100 Sardina pilchardus, 100 Caranx rhonchus, 100 Tilapia zillii, 100 Dicentrarchus punctatus) that collected randomly from Suez Canal in Ismailia Province. Some examined fishes showed sluggish movement, emaciation, and hemorrhages all over the body, beside abdominal distension, congestion of internal organs, and enteritis. Encapsulated plerocercoids were detected in the abdominal cavity and liver. The total prevalence of parasitic infestation was 66.0% (highest in autumn (76.8%) and the lowest in summer 44.8%). The highest parasitic prevalence was recorded in Engraulis encrasicolus (75%), followed by Dicentrarchus punctatus (72%), Tilapia zillii (69%), Caranx rhoncus (67%) then Sardina pilchardus (47%). The isolated parasites were digenetic trematodes (encysted metacercariae, Erilepturus hamati, Erilepturus tiegsi and Clupenuroide sp.) and cestodal larvae (Callitetrarhyncus sp. and plerocercoid). Cestodal plerocercoids were the highest prevailing parasites (28.6%). A negative correlation between infestation and fish body weights were detected. Confirmation of Callitetrarhynchus plerocercoid was done using PCR. Histopathological changes were also recorded in the infested fishes. It could be concluded that infestation with digeneasis and larval cestodiasis might have negative impacts on fish health.