The current study describes the first report on condition factors (Fulton's, K_F; allometric, K_A; relative, K_R and relative weight, W_R) of Panna heterolepis in relation to eco-climatic factors (temperature, rainfall, dissolved oxygen and pH) in the Bay of Bengal, SW Bangladesh. All together 1224 specimens (male = 654, female = 570) were caught through January to December 2019. Bodyweight (BW), as well as total length (TL), was assessed by digital balance and measuring board with 0.01 g and 0.01 cm accuracy. TL was varied between 10.70-31.40 cm for males and 10.50-34.50 cm for females. Further, BW was ranged from 10.02-203.89 g for males and 9.02- 342.26 g for the female population. The K_F values ranged from 0.56 to 1.12 for males and 0.60 to 1.45 for females. On the other hand, K_A varied between 0.0047 to 0.0212 for males and 0.0050 to 0.0267 for females. Besides, K_R varied between 0.79 to 1.39 for males and 0.73 to 1.55 for females. However, W_R ranged from 78.55 to 139.24 for males and 73.24 to 154.47 for females. Fulton's condition factor (K_F)was found the best for evaluating the well-being of this species in the Bay of Bengal. Further, K_F was found significantly related to temperature for both males (P = 0.04) and females (P = 0.04) but not with other factors. The mean W_R indicated that the habitat was in a balanced condition considering prey-predator status. The outcomes of the study will be helpful for future management of this fish in the Bay of Bengal considering the emerging climate change.