The present study documents the possible effects of Tinospora cordifolia leaf extract supplemented diets on growth, survival and haemato-biochemical profiles of the catfish, Pangasius sutchi fingerlings. P. sutchi fingerlings were fed with formulated diets, supplemented with four different concentrations of T. cordifolia leaf extract (viz. 100, 200, 400 and 800 mg kg^-1 of feed) for 45 days. Fingerlings fed with basal diet served as control. Various parameters of serum biochemical and haematology such as serum total protein content, albumin content, globulin content, albumin globulin ratio, glucose, erythrocytes count, leucocytes count were evaluated along with growth parameters. The results indicated that Specific Growth Rate (SGR), Feed Conversion Ratio (FCR), Protein Efficiency Ratio (PER), survival and Haemato-biochemical profiles such as total serum protein, albumin, globulin, albumin globulin ratio and serum glucose were high in the fingerlings fed with T. cordifolia leaf extract supplemented diets, irrespective of dosage, compared to control. Among the four concentrations of T. cordifolia leaf extract used, 200 mg/kg of feed group showed increased growth, survival and enhanced the health status of P. sutchi fingerlings.