A 56-day feeding trial was carried out to determine the effect of processing time, inclusion level and/or interaction of Luffa cylindrica seedmeal on the growth and economic performance of Clarias gariepinus. The experiment was designed to include processing times (of 5- and 10- minutes toasting) and inclusion levels (of 15 and 30% Luffa cylindrica) making four test dietary treatments. A diet without Luffa cylindrica seedmeal served as control. A total of 225 Clarias gariepinus juveniles (4.30g average weight) were distributed equally into fifteen experimental 70-litre capacity aerated rectangular plastic tanks. Triplicate groups of each treatment were made. Fish were fed 5% body weight on two equal proportions per day for 56 days.  The results of the experiment showed Distinct variations (p<0.05) existed on the effect of processing time on the growth performance parameters, the effect of 5-minutes toasted series on growth parameters were significantly different (p<0.05) from 10-minute toasted series. 15% replacement levels had significantly higher (p<0.05) effects on growth performance parameters than 30% replacement levels. The 10-minute toasted series had higher gross margin and net return but significantly (p<0.05) lesser than control. However, fish produced by D1030T yielded a significantly higher gross margin and net return than the other test diets.