Two species of octopuses were collected from Abu Quir, Alexandria, Egypt, Octpus vulgans and Octopus macropus. The mantle muscles were fixed in absolute ethyl alcohol. DNA was extracted and RAPD-PCR was conducted using 4 primers. The distance morphometric analysis of two species was applied on Arm length, Mantle length, Mantle width and body weight. The estimation of genetic distance was 0.55. In addition, morphometric studies showed no significant difference in mantle length and mantle width in both males and females. On the other hand, Arm length and body weight of 50% of males and females showed significant differences. In conclusion, the result of RAPD- PCR together with the morphometric may suggest that the two species may be two subspecies.