This study was conducted as an attempt to investigate the antimicrobial activity of Lucilia sericata (Diptera: Calliphoridae) maggots whole body extracts produced by different solvents against some bacterial and fungal strains, and also to study the role of L. sericata maggot extracts as antiviral therapeutic agents. Results showed that the highest antibacterial activity was attained by petroleum ether extract 24h post-treatment for both Gram-positive and Gram-negative bacteria either by Microbial Growth Inhibition method or by Minimum Inhibitory Concentration method. Regarding the antifungal activity, all tested extracts showed antifungal activity against tested fungal strains and it may be arranged in descending order as the following: Petroleum Ether> Hexane > Ethyl Acetate > acetone. In addition, the antiviral activity was determined and the maximum non-toxic concentration was 39.06µg/ml. The obtained results explained that petroleum ether extract was effective as anti-HSV with anti-viral activity percent of 92.9. Generally, the available results indicate that L. sericata maggot extracts induced remarkable effects on both antimicrobial and antiviral activities.