The present study aims to experiment the efficiency of marine actinomycetes in ammonia and orthophosphates removing from domestic wastewaters collected from El-Gona Wastewater Treatment Station, Hurghada, Red Sea. Ten marine actinomycets isolates were isolated from sediments in the Suez Gulf and identified as: Kocuria palustris, Streptomyces parvus, Streptomyces griseorubens, Streptomyces rochei, Streptomyces albidoflavus, Streptomyces griseus and four belonged to Streptomyces sp based on their 16S rRNA gene sequence analysis. The results demonstrated that, the experimented actinomycetes have differential effectiveness in the domestic wastewater treatment and have significant abilities to remove ammonia and orthophosphates. Streptomyces griseorubens and Streptomyces griseus are more efficient organisms in ammonia and orthophosphates removal (77.35, 79.02%, respectively) from the raw wastewater relative to the other strains.