The concentrations of heavy metals Cu, Cd, Pb, and Zn in the Abu-Qir water and in the edible portions of the inhabitant common invertebrate Portunus pelagicus were determined in the period (spring 2016- winter 2017). Generally, there was an increasing in the concentration of these measured elements comparing with the previous studies. The obtained data indicated a seasonal and spatial variation of heavy metals concentrations. The highest concentrations in the bay water were recorded during summer season, while spring showed the minimum values. On the other hand, the element levels in the crabtissue were the maximum during autumn and the minimum during winter, among the measured heavy metals Pb was the highest concentration element both in the water and in the animal tissues. It was noticed that the site located near the connection with Lake Edku (Lake-Bay connection) recorded the maximum readings which reveals the effect of the discharged water from the lake.