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30238

Monitoring of Oxidative Stress Biomarkers and Toxicity of Lead and Mercury in Catfish of Lake Mariout, Egypt: The Role of Meso -2, 3-Dimercaptosuccinic Acid (DMSA)

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Last updated: 23 Dec 2024

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Abstract

The present investigation was designed to evaluate the dangerous effects of the Pb and Hg on Clarias gariepinus inhabiting Lake Mariout and assay the possible protective effect of meso-2, 3 dimercaptosuccinic acid (DMSA). The test fish were divided into four groups kept in plastic tanks (20 fish each) containing 30L of Lake Mariout water. Group (1): Standard group (zero time); Group (2): Unexposed DMSA group, Group (3): Low dose DMSA group; Group (4): High dose DMSA group. Fish exposed to DMSA showed significant decrease in lead (P≤0.05)  and  mercury concentrations (P≤0.05) in kidney, liver, gills, muscle and blood than unexposed group. The present results clearly indicate a significant decrease in RBCs, Hb, Hct, and platelet counts while a significant  increase in MCH, MCHC, and WBCs in the Clarias gariepinus collected from the main basin of Lake Mariout. A marked significant decrease in AST, ALT, urea, creatinine  (P≤0.05) was observed in DMSA groups. A significant increase in CAT, GPX and SOD was observed after exposure to DMSA. In addition, DMSA exposure improved the histopathological alterations in fish liver and kidney. 

DOI

10.21608/ejabf.2019.30238

Keywords

Monitoring, Oxidative Stress, Lead, mercury, toxicity, catfish, Lake Mariout

Authors

First Name

Nema

Last Name

A. Mohamed

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First Name

Awatef

Last Name

M. Ali

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First Name

Shnoudy

Last Name

A. Bakhoum

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First Name

Heba

Last Name

H. Abdel-Kader

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First Name

Mohamed

Last Name

A. Ahmed

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Volume

23

Article Issue

2

Related Issue

5152

Issue Date

2019-04-01

Receive Date

2019-02-19

Publish Date

2019-04-16

Page Start

165

Page End

182

Print ISSN

1110-6131

Online ISSN

2536-9814

Article File

EJABF_Volume 23_Issue 2_Pages 165-182.pdf

PDF . 1.1MB

Link

https://ejabf.journals.ekb.eg/article_30238.html

Detail API

https://ejabf.journals.ekb.eg/service?article_code=30238

Order

13

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Original Article

Type Code

103

Publication Type

Journal

Publication Title

Egyptian Journal of Aquatic Biology and Fisheries

Publication Link

https://ejabf.journals.ekb.eg/

MainTitle

Monitoring of Oxidative Stress Biomarkers and Toxicity of Lead and Mercury in Catfish of Lake Mariout, Egypt: The Role of Meso -2, 3-Dimercaptosuccinic Acid (DMSA)

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Article

Created At

22 Jan 2023