Adding natural product such as Humic acid (Humabol) and Yucca schidigera extract to enhance water quality under scarce water exchange regiment; has numerus effects on both fish environment and health. Yucca showed significant reduction on NH₃ and NO₂ levels, while humic acid showed significant reduction on orthophosphate and total phosphorus compared to negative control; in addition to maintaining acceptable growth rate under designed experimental conditions. Furthermore, the hematological study showed that, Yucca and humic had positive effect on Red cell indices values such as, HCT, MCV, MCH, MCHC as well as WBCs total count and the proportion of the NEU, MONO, ESO and LYM of the treated treatments. Also, the histological study of gills, liver, stomach and intestine highlighted the tissue protective effect manifested by Yucca and humic.