Fungal activities to remove and/or degrade heavy metals in industrial waste water were studied. Water samples were collected from the waste water main drain station in industrial area in Port Said. A total of 55 isolates were grown on 4 types of cultures media. Macroscopically and morphological examination results also showed that among these isolates15are belonging to fungi; 12 isolates are belonging to actinobacteria, whereas 28 isolates are belonging to bacteria. The 15 fungal isolates were screened for their ability to degrade some heavy metals reported in industrial waste water. Aspergillus niger and Aspergillus flavus were reported as the most active organisms in degrading of heavy metals detected in industrial waste water.