Lake Manzala is the largest Nile Delta, coastal ecosystem in Egypt. To examine of the pollution in the lake, the levels of some heavy metals (Fe, Mn, Zn, Cu, Pb, Ni, Cd and Co) were assessed in water samples collected from twelve stations covering the southern region of the lake area, seasonally from the spring 2014 to winter 2015. The lake has undergone substantial recent changes particularly over the last 30 years due to increasing the inflows of drainage water, land reclamation and increasing loads of pollutants. The obtained results confirmed that, industrial, agricultural and domestic sewage drained into the lake from the main drains has a considerable impact on the water quality characteristics of the lake. The concentration of heavy metals varied in a wide range; increased in the southern region and decreased towards north eastern part of the lake. Heavy metals discharged into the lake causes a momentous environmental problem.