Wastewater originating from the textile-dying industries is a complex mixture of potentially polluted substances consisting of textile dyes, heavy metals associated with dyes and other auxiliaries used during dyeing process. The present study was conducted in an attempt to examine the physical, chemical and microbial changes as a result of industrial wastewater discharge into the main drain station in the industrial free zone area at Port Said, Egypt. Results showed that physical, chemical and microbial characteristics of water are deteriorated and many of these parameters figures exceeded the legislation limits. However, considering the textile industry, an increase is expected in concentrations of turbidity and TSS as a consequence of the exceeding amounts of fibers encountered in this industry 102 pure identified actinobacterial isolated previously were tested and proved to be capable of degrading industrial pollutants applied. The 102 isolates were screened to explore their capability with the effluent of the factory of Dolphin .Isolate N° Ndd7 proved and showed the highest ability to degrade the main dye used in the industrial process in the factory.