Assessment of levels of some metals (Cu, Cd, Pb, Ni, Co, Zn and Fe ) was studied in fish, Tilapia sp., tissues collected from Manzala, Timsah, Nasser Lakes, and the River Nile infront of Cairo City. Gills and liver of fish showed higher
metals concentration than those found in muscles (edible part). The lowest values of studied metals were recorded in the muscles of Nasser Lake fish. However, data of metals concentration in fish tissues were not fairly reflecting the status of lake contamination. While, the c/w ratio (c: metal concentration, w: fish weight) caused considerable changes in the pattern of metals variation between different sites. This ratio indicates that the Manzala Lake is heavily polluted by metals than other sites.