An experimental study was conducted to evaluate the effect of three different natural growth promoters as feed additives on growth performance of monosex Nile tilapia fingerlings. Three nutritional treatments were applied at two additive levels (0.15 & 0.3 %) of Paprika (Hot Red Pepper “Capsicum annuum" meal), Proplis (Bee Glue) and Humapol-FIS Substance (Humic & Fulvic acids with Mixture of Minerals) each one in addition to Control diet. The tested treatments were conducted in two cement ponds (8×4×1 m), divided with nets to 16 equal aquatic compartments (2×2×1
m); 14 of them were used and stocked randomly with 20 fish/each one with an average initial body weight of 23.62 ± 0.13 g. The experiment lasted for 20 weeks (Six feeding days/week with the feeding rate at 3% of live body weight/day). The results at the end of the experiment showedthat, growth performance and feed conversion ratio were significantly (P< 0.05) improved for monosex tilapia fingerlings fed on diets with the aforementioned natural feed additives compared to fish fed on the control diet. Feed cost required to produce 1kg weight gain compared
to fish fed on the control diet was reduced by using the feed additives. These results revealed that using Proplis (P) at a dietary additive level of 0.3 % was the best treatment in terms of growth performance and feed utilization, while the highest revenue and the best economic evaluation were obtained from the Paprika (K) diet at a level of 0.3 % compared to the control diet.