Bisphenol A (BPA) is an industrial chemical, used to manufacture polycarbonate and numerous plastic articles and leach to salt and fresh water. Low levels of BPA have also been found to cause biological effects, and its mode of action
appears to mimic that of the female hormone, estrogen. BPA therefore belongs to a group of chemicals termed “hormone disruptors" or “endocrine disruptors" that areable to disrupt the chemical messenger system in the body. The present study is aimed  to assess the histological changes caused to the kidney tissues of both mosquito-fish
(Gambusia affinis) and a guppy-fish (Poecilia reticulata) as a result of exposure to bisphenol A. These poeciliid fishes were exposed to 50μg/l of bisphenol A for 15 days (short term) and 30 days (long term). Histological examination of the kidney treated with Bisphenol A in both fish species showed a variety of histopathological effects; like inter tubular edema, shrinkage of glomeruli, glomerular distortion, vaculation of tubular cells, necrosis and atrophy of renal tubules, severe congestion and blood hemolysis, fluid stagnation in renal tubules and moderate aggregation of macrophages.
In conclusions, our study concluded that, the concentration 50μg/l of BPA has ability to induce harmful effect on the kidney tissue of fishes and these effects are time dependent.