The water quality of Lake Manzala was studied seasonallyJ during the period from autumn 2000 to summer 2001. The results of physical parameters revealed that the values of transparency at the southern region are relatively low and reflect the type of effluents, characterized by high amounts of floating materials, which decrease the water transparency. Moreover, the electrical conductivity at these stations were somewhat high as a result of sewage and industrial wastes at that region. On the other hand, the chemical analysis of water showed high values of chemical oxygen demand (COD) and biological oxygen demand (BOD) but low levels of dissolved oxygen (DO) especially at the southern region opposite to Hadous and Bahr El-Baqar drains, in addition to high levels of trace metals.