Fish samples of Solea vulgaris. Mugil cephalus, Liza ramada and Spams aurata were collected during November 2001 from El Telol location in Bardawil lagoon, north eastern of Egyptian Mediterranean coast. The study was conducted to assess the effect of the heavy metals (Fe. Mn. Zm Cm Pb and Cd) and the macro nutrients (Na, K, Ca, and Mg) on livers tissues of the four fish species. The results showed that the concentrations of Fe, Mn, Zn, Cu, Pb, and Cd in the livers of the four fish species ranged between 48.680- 121.940, 1.270* 2.170. 15.220- 32.570. 82.280- 30L830. 1.100- 4.960 and
0.180- 0.300 mg/ Kg respectively. The concentrations of Na, K. Ca and Mg in the livers of the four species ranged between 1131.60- 1702.00, 327.60- 507.00, 74.490- 398.300 and 72.180- 170.590 mg/Kg respectively. Microscopical examination of livers tissues of Solea vulgaris, Liza ramada* Mugil cephalus and Spams aurata showed different degrees of injuries, including fatty degeneration, ballooning degeneration, accumulation of hemosiderin pigment and necrosis.