This study deals with the effect of aquatic environmental pollution of Lake Manzalah on Lizaramada. The fish and water samples were collected seasonally for a year from Autumn 2000 to Summer 2001 from the selected stations near Boughaz El-Gamil. Other water samples were collected from 12 different stations in other locations. The study included heavy metal analysis of the water lake and histopathological changes in the kidneys of the same fish. The investigation revealed that the high values of heavy metals (Fe, Mn, Cu, Zn, Pb and Cd) encountered during the different seasons in lake Manzalah induced toxic effects on Lizaramada kidneys which may decrease the productivity of this Mugil species. So, it is recommended to try to protect this fish from the destruction by drainage water loaded with agricultural and industrial pollutants as well as sewage.