Four artificial diets were formulated to contain four carbohydrate to tipid ratios (CHO/ L) (2, 4, 6 and 8). The gross energy of each diet was adjusted by balancing the biscuit industry by - product as a carbohydrate .source and cotton seed oil mix to provide four tested CHO:L ratios. The diets were used to determine the optimum dietary level of CIIO:L ratio for two sizes of hybrid tilpia initially weighing 10.0 and 80.0g for 160 days.Growth values were better with feed 4CHO:L ratio for the smaller fish, whereas similar (4) CHO:L ratio yielded the highest feed conversion efficiency, protein, energy and lipid retained for the same size (with the starting average weight 10.Og respectively). However, feeds with 6 CHO:L ratio proved better in large hybrid tilapia (initially weighing 80.Og). The hepatosomatic index showed higher values for feeds with 8 CHO:L ratio in the case of small and large fish, but the opposite was observed for liver lipid content which showed a tendency toward higher values for 2 CHO:L ratio in both small and large hybrid tilapia. These data suggest that small hybrid tilapia can perform well with diet containing 4 CHO:L ratio, whereas large fish may be as efficiently at 6 CHO:L ratio