The cuttlefish Sepia dollfusi was collected from the Gulf of Suez during April 1996 - May 1997. The body and shell measurements for different length groups were determined. The constants (a & n) of the length-weight relationship were 0.4993 and 2.456, respectively. The growth curves of this species indicated that its life span extends to about two years. The parameters of growth (L, K, to & W∞) were computed using different methods. The Bertalanffy growth model
was recommended to be used for studying the theoretical growth in length and weight for animals belonging to the Family Sepiidae. The overall growth performance (phi prime, Ø ) was 5.778. This can be used to distinguish this species from other related ones. The spawning season of females starts in spring as shown from their gonado-somatic
index. The coefficients of natural, fishing and total mortalities were 2.066, 2.954 and 5.020 per year, respectively. The present study indicated that the stock of S. dollfrsi was slightly overexploited. The yield per recruit was estimated to be 34 g for specimens of age 0.65year at first capture (tc) and with 2.95 per year fishing mortality (F).