The present study was carried out in a private farm (El-Assuity Valley) Assuit Governorate, Egypt, during two successive seasons (2003 and 2004) to investigate the response of pomegranate (Manfalouty cv.) trees to different rates of nitrogen (400 and 800 g/tree), Phosphorus (150 and 300 g/tree) and potassium (250, 500 and 750 g/tree) fertilizers through the possible combinations between the investigated fertilizers rates. Generally, the obtained data showed that, the highest values of perfect flowers percentage was recorded at the beginning of flowering season (April 18^th), while, the lowest values was recorded at the end of flowering season (June 1^st). In this respect, the highest value was recorded when N:P:K fertilizers were applied at 800:300:750 g/tree/year. It is clear that, initial fruit set was significantly higher at flowering dates before full bloom, while, the lowest values were recorded at the end of flowering season. However, the pronounced effect on initial fruit set was mostly referred to N, P and K fertilization treatments. N:P:K at 400:300:500g/tree/year, was the most effective treatment. In addition, application of nitrogen at 800, phosphorus at 150 and potassium at 250 or 500 g/tree/year gave the highest yield, least fruit splitting and improved of fruit quality. However, the lowest acidity % and the highest ratio of T.S.S./acid were obtained from N, P, K at the rates of 400, 300 and 175 or 800, 150 and 250 g/tree/year. In addition, application of nitrogen at 400 g, phosphorus at 300g and potassium at 500 or 750 g gave the best results concerning the commercial fruit yield. As a conclusion, a combination of N:P:K fertilizers at 800:150:250 or 500g/tree/ year can be recommended for pomegranate (Manfalouty cv.) fertilization programme, to increase fruit yield/tree, improve fruit quality and decrease fruit splitting % .