This work was carried out during two successive winter seasons of 2003 and 2004 at Arab El-Awammer Research Station., Agric Res. Center (A.R.C)., Assiut Governorate to study the effect of different rates of Nitrogen, Phosphorus and Potassium fertilizer on growth, yield, quality and chemical composition of potato leaves in sandy calcareous soils under drip irrigation systems. Applying N at a rate of 120 kg/fed, P at a rate of 60 kg P₂O₅/fed and K at a rate of 60 kg K₂O/fed. significantly affected growth parameters of potato plants including plant height, weight of vines/plant and number of sponts/plant, Applying N at a rate of 120 kg/fed, P at a rate of 30 kg P₂O₅/fed and K at a rate of 60 kg K₂O/fed. gave the highest weight of marketable tubers/fed and gave the highest percentages of tuber dry matter in both seasons. Nitrogen, P and K concentration in potato plant leaves was significantly affected with increasing N, P and K rates. Maximum values of N, P and K contents in potato plant leaves was obtained from 180 N/fed., 90 kg P₂O₅/fed and 60 kg K₂O/fed