Drip fertigation experiments were conducted for two seasons to determine the effect of four irrigation periods (0.25, 0.50, 0.75, and 1.0 h every 2 days intervals) which delivered four amount of irrigation water (980, 1960, 2940, and 3920 m3 fed-1 ) in combination with injection of three levels of nitrogen fertilizers (15, 30 and 60 Kg N/feddan) on peanut (Giza-6) yield, and water use efficiency, as well as moisture and salt distribution in the root zone of soil were studied. Results indicated that the changes in soil moisture content in the root zone were correlated with the applied amounts of irrigation water. The soil under the dripper were leached from salt with increasing amount of irrigation water. Peanut yield was significantly increased with the increasing irrigation water level and N fertilizer in the two seasons. However, water use efficiency (WUE) and irrigation water use efficiency (IWUE) were decreased with increasing the applied irrigation water. In conclusion, applying N at the highest rate (60 kg/fed) with 2940 m3 fed-1 irrigation water treatment, which is nonstress water treatment, produced the highest yield of peanut plants.