Three contaminated soils at Helwan, El-Gabal El-Asfar (Cairo governorate) and Arab El-Madabeg (Assiut governorate) were chosen in a leaching column experiment for 8 weeks to study the effect of certain organic materials on the mobility of some heavy metals (Pb and Cu) in these soils. The organic materials including ethylene diamine tetra acetic acid (EDTA) as a synthetic organic material as well as poultry litter extract (PLE), vinasse (V) and humic acid (HA) solutions as natural organic materials, compared to distilled water as a control. These solutions were added to the column every week at levels of 2, 4 and 6 mmols/kg for EDTA, 25, 50 and 75 g/L for PLE , 1:2 and 1:1 dilutions of Vinasse to water as well as pure V, and 0.013, 0.019 and 0.025 % for HA. The results indicated that leaching the studied soils with different organic materials at various levels of application resulted in increases in the mobility of soil Pb and Cu. The magnitude of soil Pb and Cu mobility varied depending upon the type of organic material, its application level and the soil type. The studied organic materials differed in their efficiency in moving Pb and Cu from the top to the bottom of the soil columns. EDTA was found to be the most effective organic material, especially at its highest level. Generally, the investigated organic materials had the order of EDTA > Vinase > PLE > HA in mobilizing soil Pb and Cu in the studied soils.