This study was carried out during the three successive seasons of 2005, 2006 and 2007 at the Experimental Orchard, Assiut University, Egypt on Manfalouty pomegranate cultivar.  Four tree groups were selected each of which have almost the same inclination angle of 90° (control), 60°, 45° and 30° from the soil surface in order to study the effect of tree inclination angle on the growth, yield and fruit quality. The increase in the tree-inclination led to a significant increase in the number of suckers in the other direction of inclination of the main trunk. The 90 degree angle of inclination led to a significant increase in the upper shoot length (cm), fruit set (%), yield (kg), commercial yield (%), average fruit weight (g), grains weight (%), total soluble solids (%), reducing sugars (%) in addition to significant reductions in both of fruit splitting (%) and total acidity (%).  Whereas, the reverse occurred as the inclination angle decreased gradually to 60° or 45° or 30° especially in the following seasons. The results recommended keeping the growth of trees approximately vertical (90° inclination angle) in order to reduce the growing of suckers on the strong trunk.  This can be done through training a single trunk which would consequently increase the fruit set, yield and fruit quality and decrease fruit-splitting (%) under the conditions of experiment.