This experiment was conducted in the experimental orchard of the faculty of Agriculture, Assiut University during 2020 and 2021 seasons to investigate the response of Red Roomy grapevines to spray with Sitofex (CPPU) at 2.5 ppm, moringa leaf, pomegranate peel and turmeric rhizome extracts each at 2 and 4%. The experimental was arranged in a randomized complete block design (RCBD) involved eight treatments of three replicates, one vine each. Pruning wood weight, leaf area and total leaf chlorophyll were significantly increased by spraying with all extracts. There was no significant effect of CPPU on these vegetative traits, TSS and reducing sugar compared with control. All foliar applications were very effective on improving yield components and physical quality characters. Extracts significantly improved the TSS, reducing sugar and skin anthocyanin of berries compared to control and CPPU. These extracts significantly decreased total acidity compared to control and CPPU. It could be concluded that spraying all extracts three times annually was necessary to get high yield with good cluster and berry quality. Hence, from an economic point of view, it is preferable to use 2% from all these extracts treatments. Moreover, it is very safe for human, animals and the environment in terms of less pollution and reduces total production cost.