In the present study, we estimated the yield and its attributes as well as water use efficiency of two bread wheat cultivars, i.e., Shandaweel-1 and Giza-171 under three irrigation intervals, i.e., irrigation every 6, 9 and 12 days, and three concentrations of salicylic acid, i.e., 0.0, 150, and 300 ppm which was done at a  private farm in the village of Al-Ghuraira, Esna center, Luxor governorate upper Egypt during 2018/2019 and 2019/2020 seasons. This study was laid out in a strip-split plot arrangement was based on a randomized complete block design (RCBD) with three replications. The results indicated that increasing irrigation intervals (I) from 6 up to 9 or 12 days significantly decreased vegetative traits, yield and yield attributes traits, i.e., plant height, flag leaf area, spike length., number of kernels spike^-1, kernels weight spike^-1, 1000-grain weight as well as grain yield fed.^-1, but significantly increased grain protein content (%), water use efficiency (WUE) and water saving% in both seasons. The Foliar application of 300 ppm of salicylic acid (SA₃) had significantly increased all the yield and its attributes traits compared to the control treatment (SA₁) As well as improving WUE under the conditions of irrigation periods every 9 and 12 days. Shandaweel-1 cultivar outperformed Giza-171 cultivar in plant height, spike length, grain yield and WUE in both seasons, and number of kernels spike^{-1 in the 1st} season. Likewise, Giza-171 surpassed Shandaweel-1 in flag leaf area, kernels weight spike^-1, 1000-grain weight and protein% in both seasons, and number of kernels spike^{-1 in 2nd} season. Furthermore, the second order interaction I₆×SA₃×WC₂ gave the highest value for 1000-grain weight (78.0 g) in the 1^st season only.