This study was designed to evaluate the influence of sweet basil (Ocimum basilicum L.) leaves extracts on growth performance indicators, physiological and hematological responses in mice orally exposed to phenol. Sixty-six male Swiss albino mice were divided into eleven groups. The 1st one assigned as a control. The 2nd group was daily oral exposed to 180 mg C6H5OH / kg body weight for 21 days. 3rd, 4th and 5th groups were daily oral received basil leaves hexane extract (BLHE), basil leaves ethanol extract (BLEE) and basil leaves aqueous extract (BLAE) by 400 mg / kg body weight for 21 days respectively. The 6th, 7th and 8th groups were daily oral exposed to BLHE, BLEE and BLAE by 400mg / kg body weight for 21 days respectively after exposure to 180mg C6H5OH / kg body weight for 21 days. Finally, 9th, 10th and 11th groups were daily oral received BLHE, BLEE and BLAE by 400 mg / kg body weight for 21 days respectively before exposure to 180 mg C6H5OH / kg body weight for 21 days. As a response of phenol administration, the liver % reduced while the kidney %, spleen %, and testis % were increased. Hematological indicators, such as RBCs, Hb %, and PCV %, showed a significant increase. Basil leaves extracts improved some growth performance indicators, reduced phenol adverse effects on several organs and hematological parameters. These findings show that basil leaves extracts can be used as an anti-toxin agent with a wide range of health benefits.