This study was conducted during 2018, 2019 and 2020 seasons, on 10 years old Flame Seedless grapevines, grown on the experimental vineyard of the Research Station, Matana, Esna, Luxor, Egypt to study the effect of antioxidants on vegetative growth, nutrient status, and fruiting of Flame Seedless grapevine. The experiment was arranged in a complete randomized block design with four treatments and three replications two vine per each.
The obtained results could be summarized as follow:

Spraying either citric acid, ascorbic acid or vitamin B₁₂ significantly increased, pruning wood weight and leaf area as well as leaf total chlorophyll and leaf nutrient composition compared to spray water ones (check treatment). No significant differences on these traits due to spray with any ones compared to either. All antioxidants treatments significantly increased the yield and improved the cluster and berry traits compared to sprayed water. It is evident from the foregoing results that spraying with either ascorbic acid or citric acid or vitamin B₁₂ at 250 ppm three times improved the vegetative growth, yield and berry quality.