Field experiments were conducted at Shandaweel Agricultural Research Station, during the three winter successive seasons (2012/2013, 2013/2014 and 2014/2015) to find out the effect of different dates and irrigation regimes on growth, yield and consumptive use of three wheat varieties under Sohag governorate conditions. Three bread wheat cultivars (Shandaweel-1, Giza-168 and Sids-12) were cultivated in two different sowing dates (20^th November and 5^h December) under three irrigation intervals treatments of 21, 28 and 35 days. The experiment was laid out in a split – split plot design with three replications. The results revealed significant differences among studied cultivars and irrigation treatments in most studied traits in all seasons. The second sowing date 5^th December produced the best results of the growth components, grain yield and water use efficiency through the years of this study. The irrigation at 21 days gave the best values of grain yield values (18.234, 16.609 and 17.198 ardab/fed) for the three winter seasons 2012/13, 2013/14 and 2014/15. The average water consumptive use by wheat plants were 2094.48 for I₁, 1883.46 for I₂ and 1564.15 for I₃   m³/fed. at the first sowing date (20^th Nov.) while it was  2123.93 for I₁, 1811.49 for I₂, and 1606.19 for I₃ m³ /fed for the second sowing date (5^th Dec.). The irrigation water use efficiency was higher with using the irrigation treatment every 35 days. It was 0.53, 0.54, and 0.61 kgm^-3 for the first sowing date (20^th November) and it was 0.64, 0.68, and 0.68 kgm^-3 for the second sowing date (5^th December) by using the irrigation interval treatment at 21, 28, and 35 days, respectively.   Shandaweel 1 produced the highest values of grain yield and water use efficiency at the two sowing dates and the irrigation regimes. Also the results of the second sowing date (5^th December) for Shandaweel 1 were higher than these of first sowing date.