The effect of salicylic acid (SA) on pomegranate seedlings (Manfalouty cultivar) infected with root-knot nematode, Meloidogyne javanica was studied in this research. Salicylic acid was applied with different concentrations (0,10 and 40 mM) on foliar and soil drenching. Some traits and characteristics were determined, i.e. shoot and root lengths (cm), shoot and root fresh and dry biomass (g), nematodes reproduction, potassium and magnesium mg/g of both shoot and root, total chlorophyll content and total carbohydrates content (g/100g). Results showed that treated seedlings with SA had a healthier appearance under nematode infection, compare to untreated ones. Moreover, SA significantly enhanced most of vegetative growth parameters, and increased the potassium and magnesium uptake as well as their translocation from root to shoot, and increased the total carbohydrates content. Results also reveal that, all treatments either spraying or drenching significantly reduced all related nematode parameters i.e. number of galls/g root, number of egg masses/g root, as well as number of juveniles/100 g soil (after 45 or 90 days) compared to untreated plants.