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271965

Reishi Mushroom (Ganoderma lucidum) Intervention Improves Lipids Profile and Paraoxonase/Arylesterase Activities in Serum as well as Enhances Haemostatic Effects in Streptozotoci

Article

Last updated: 01 Jan 2025

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Tags

Food Science and technology

Abstract

Several strategies have been proposed to improve diabetes mellitus (DM) complications, because early treatment and prevention play a pivotal role in reducing the population burden of this disease. The benefits of pharmaceutical agents for treating the disease have long been recommended, but medications may have unwanted side effects. Therefore, the present study was carried out to investigate the potential effects of Ganoderma lucidum ethanol extract (GLE) intervention in modulating the hyperglycemia, serum lipids profile and serum paraoxonase/arylesterase activities, andhaemostatic effects in streptozotocin-induced diabetic rats. Thirty-six male adult male Sprague-Dawley rats were randomly divided into equal six groups. Group 1: Normal control, normal rats feed with basal diet (BD); Group 2: Model control, diabetic rats feed with BD without intervention; Groups 3-6: GLE, diabetic rats with BD, intervention groups utilizing GLE of 200, 400, 600 and 800 mg/kg bw by oral gavages for 28 consecutive days. Type 2 diabetic rats were obtained by Streptozotocin (STZ) injection. Treatment of rats with streptozotocin caused a significant increased (p < /em>≤0.05) in serum glucose, triglycerides (TG), total cholesterol (TC) and reactive oxygen species (ROS) concentrations by the ratio of 200.13, 554.05, 71.97 and 30.62% compared to normal controls, respectively. The opposite direction was recorded for the high-density lipoprotein cholesterol (HDL-c) and antioxidant enzymes paraoxonase/arylesterase activities which decreased by the ratio of -57.95%, -50.81 and -41.32% compared to normal controls, respectively. Additionally, haemostatic effects (bleeding and clotting times) were increased in different periods of times (7, 14, 21 and 28 days). GLE intervention greatly ameliorated the hyperglycemia, serum lipid profiles, ROS and haemostatic effects in diabetic rats. The rate of amelioration(s) was exhibited a dose- dependent increase with GLE intervention. In conclusion, data of this study provided a basis for the use of GLE for the prevention and/or treatment of type-2 Diabetes mellitus complications such as hyperglycemia, oxidative stress and blood bleeding. 
 

DOI

10.21608/asejaiqjsae.2022.271965

Keywords

body weight, Reactive oxygen species, Antioxidant enzymes, Bleeding time, clotting time

Authors

First Name

Alaa

Last Name

O. Aboraya

MiddleName

-

Affiliation

Department of Nutrition and Food Science, Faculty of Home Economics, Helwan University, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Yousif Abd Elasis Elhassaneen

Last Name

Elhassaneen

MiddleName

-

Affiliation

Department of Nutrition and Food Science, Faculty of Home Economics, Minoufiya University, Shebin El-Kom, Egypt

Email

yousif12@hotmail.com

City

Shebin El-Kom,

Orcid

0000-0003-1391-3653

First Name

Olfat

Last Name

M. Nassar

MiddleName

-

Affiliation

Department of Nutrition and Food Science, Faculty of Home Economics, Minoufiya University, Shebin El-Kom, Egypt.

Email

-

City

-

Orcid

-

Volume

43

Article Issue

4

Related Issue

37463

Issue Date

2022-12-01

Receive Date

2022-10-25

Publish Date

2022-12-30

Page Start

593

Page End

608

Print ISSN

1110-0176

Online ISSN

2536-9784

Article File

ASEJAIQJSAE_Volume 43_Issue 4_Pages 593-608.pdf

PDF . 596.4kB

Link

https://asejaiqjsae.journals.ekb.eg/article_271965.html

Detail API

https://asejaiqjsae.journals.ekb.eg/service?article_code=271965

Order

6

Type

Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

Reishi Mushroom (Ganoderma lucidum) Intervention Improves Lipids Profile and Paraoxonase/Arylesterase Activities in Serum as well as Enhances Haemostatic Effects in Streptozotoci

Details

Type

Article

Created At

22 Jan 2023