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253659

In Vitro Effect of Cypermethrin on the Perturbations of Rat Erythrocytes: The Ameliorative Role of Carvone

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Plant pest management

Abstract

Erythrocytes are a suitable model to study the membrane oxidative injury resulted by different xenobiotic. An attempt was made to study the antioxidant property of carvone (CAR), a monoterpene presents in herbs to mitigate toxicity of cypermethrin (CYP), a type II pyrethroid, in male rat erythrocytes in vitro. Erythrocytes were prepared and exposed to CYP (25-800 μM) alone and together with CAR (40 and 320 μM). Results showed superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities were significantly decreaseed. Lipid peroxidation (LPO) level, reduced glutathione (GSH) content, both of glutathione s-transfarase (GST), and glutathione reductase (GR) activities were significantly increased in comparison of control value. Scanning electron microscope (SEM) supported the toxic effect of CYP which presented various degrees of alteration in shape and ruptured membranes. Pre-treatment of erythrocytes with CAR induced alleviation in all the tested parameters. It can be recommended that CYP induced oxidative stress in vitro in rat erythrocytes and supplementation with CAR ameliorated these effects.

DOI

10.21608/asejaiqjsae.2022.253659

Keywords

cypermethrin, Carvone, erythrocytes, oxidative damage, antioxidant status, Scanning electron microscope

Authors

First Name

Nadia

Last Name

Hamed

MiddleName

Ali

Affiliation

Mammalian & Aquatic Toxicology Department, Central Agricultural Pesticide Laboratory (CAPL), Agricultural Research Center (ARC), 21616-El-Sabahia, Alexandria, Egypt

Email

nadia010560@gmail.com

City

الاسکندرية

Orcid

-

First Name

Eman

Last Name

Mosallam

MiddleName

Mohamad

Affiliation

Mammalian & Aquatic Toxicology Department, Central Agricultural Pesticide Laboratory, Agricultural Research Center, Alexandria, Egypt

Email

eman_mosallem2006@yahoo.com

City

Alexandria, Egypt

Orcid

-

First Name

Reda

Last Name

Abdel-Razik

MiddleName

Khamis

Affiliation

Pesticides Toxicity to Mammals and Aquatic Organisms, Central Agricultural Pesticide Lab., Agricultural Research Center, Alexandria, Egypt

Email

redarazik216@gmail.com

City

Alexandria

Orcid

0000-0002-0003-744X

Volume

43

Article Issue

3

Related Issue

35754

Issue Date

2022-09-01

Receive Date

2022-07-10

Publish Date

2022-09-01

Page Start

417

Page End

429

Print ISSN

1110-0176

Online ISSN

2536-9784

Article File

ASEJAIQJSAE_Volume 43_Issue 3_Pages 417-429.pdf

PDF . 835.4kB

Link

https://asejaiqjsae.journals.ekb.eg/article_253659.html

Detail API

https://asejaiqjsae.journals.ekb.eg/service?article_code=253659

Order

3

Type

Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

In Vitro Effect of Cypermethrin on the Perturbations of Rat Erythrocytes: The Ameliorative Role of Carvone

Details

Type

Article

Created At

22 Jan 2023