This study aimed to investigate the effect of the pomegranate peel powder (PPP) on the liver enzymes, blood bilirubin, kidney functions, antioxidant activity, leptin and bone density of overweight rats.
The experiment had two phases, the first one namely the increase body weight (8 weeks), the second was the cure phase (decrease the body weight, 6 weeks). There were 5 groups, negative control fed the standard diet during the 14 weeks, and overweight group fed high fat diet. The overweight group divided into 4 groups, a positive control and 3 experimental groups fed 7.5%, 15%, and 22.5% of the PPP, respectively.
The results indicated that the PPP decreased the levels of the liver enzymes (ALT,AST, and ALP) and the blood bilirubin in comparison to the positive group. The kidney function improved (decrease the levels of blood urea and creatinine), and decrease in the oxidative stress (decrease in LDH and MDA, and increase in the enzyme GPX). Increasing the concentration of the PPP caused a decrease in the leptin and improve the bone density, as well as the liver tissues.
Adding the PPP to the overweight  rats' meal improved all of the studied biological parameters in the blood, liver, kidney, and bone.