Beta
ManageSearchChatDiscover
204858

Effects of Imidacloprid and Gestational Age on Biodistribution and Maternal Toxicity in Pregnant Mice Compared to Non- Pregnant

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Plant pest management

Abstract

Imidacloprid (IMI) is a systemic insecticide belonging to a class of chemicals called the neonicotinoids which act on the central nervous system of insects. It was the most widely used insecticide in the world. However, currently there are limited information regarding the impact of pregnancy on their biodistribution and toxicity. In this study, the biodistribution and potential toxic effects of IMI in pregnant and non–pregnant mice at different critical gestational ages (Gds 8,10,12, and 14) administrated one day treatment of 10, 15, and 20 mg/kg/d IMI by gavage were determined. Also, the effects of IMI on the biodistribution were recorded on pregnant mice administrated repeated doses of 10, 15, and 20 mg/kg/d IMI on different critical gestational days (6- 15, 8- 15, 10- 15, 12- 15, and 14- 15) compared to non- pregnant at the corresponding age. No significant biodistribution changes were observed between non-pregnant and pregnant mice treated on 8, 10, 12, and 14 Gds on all the treated groups of 10, 15, and 20 mg/kg. Apparent toxic effects (e.g., signs of toxicity, reduction in body weights and weight gains at all difference gestational days) were observed by repeated dose of 20mg/kg comparable to controls and non-pregnant. Also, there was a positive relationship between the accumulation of IMI at different gestational ages and maternal toxic effects. These results indicated that the maternal biodistribution patterns of IMI in pregnant mice dependent on dose, exposure length, and gestational ages.

DOI

10.21608/asejaiqjsae.2021.204858

Keywords

teratogenicity, Developmental toxicity, Imidacloprid

Authors

First Name

Amina T.

Last Name

Farag

MiddleName

-

Affiliation

Department of Pesticide Chemistry and Technology, Faculty of Agriculture, University of Alexandria.

Email

-

City

-

Orcid

-

First Name

Hamza S

Last Name

Abou-Elnasr

MiddleName

-

Affiliation

National Institute of Oceanography and Fisheries (NIOF), University of Alexandria.

Email

h.samir@niof.sci.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Khafagy

MiddleName

-

Affiliation

Department of Pesticide Chemistry and Technology -Agriculture faculty -ELshatby

Email

mohamedkhafaga184@yahoo.com

City

-

Orcid

-

First Name

Ezzat A

Last Name

Kadous

MiddleName

-

Affiliation

Department of Pesticide Chemistry and Technology, Faculty of Agriculture, University of Alexandria.

Email

-

City

-

Orcid

-

Volume

42

Article Issue

4

Related Issue

28123

Issue Date

2021-10-01

Receive Date

2021-10-06

Publish Date

2021-12-31

Page Start

831

Page End

849

Print ISSN

1110-0176

Online ISSN

2536-9784

Article File

ASEJAIQJSAE_Volume 42_Issue 4_Pages 831-849.pdf

PDF . 370.1kB

Link

https://asejaiqjsae.journals.ekb.eg/article_204858.html

Detail API

https://asejaiqjsae.journals.ekb.eg/service?article_code=204858

Order

5

Type

Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

Effects of Imidacloprid and Gestational Age on Biodistribution and Maternal Toxicity in Pregnant Mice Compared to Non- Pregnant

Details

Type

Article

Created At

22 Jan 2023