ManageChatDiscover
201175

Chlorfenapyr Induce Oxidative Phosphorylation Deficiency in Exposed Rat and the Quinoa Effective Role

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Plant pest management

Abstract

The present study investigates uncouple and pro-oxidant effects of chlorfenapyr (CFp) on rat liver and spleen mitochondria respiratory complexes and evaluates the quinoa seeds (Q) (30% from the basal diet) effects on CFp exposed rats. Repeated sublethal oral doses of CFp (180 mg / Kg body weight; 1/3 LD50) was given to rat. Liver and spleen mitochondria were isolated at the end of the fourth week after dosing. Changes in liver and spleen mitochondrial respiration complexes, and concomitant oxidative stress and antioxidant alterations were examined.  Since, CFp provokes a significant reduction in the activity of NADH dehydrogenase (complex I), succinate dehydrogenase (complex II), ubiquinone cytochrome c oxidoreductase (complex III), cytochrome c oxidase (complex IV), superoxide dismutase (SOD), and reduced glutathione (GSH) level. In addition, a significant increase in ATP synthase (complex V) and malondialdehyde (MDA) levels were observed in both liver and spleen mitochondria, indicating clearly an intense peroxidation within mitochondria. So, the results conclude that hepatic and splenic respiratory complexes in rats were severely compromised following CFp exposure. Moreover, Q enhanced diet neutralizes the CFp adverse effect that encourages its use as a mitochondrial enriches source and a protective antioxidant food supplement.
 

DOI

10.21608/asejaiqjsae.2021.201175

Keywords

chlorfenapyr, Electron transport chain, mitochondria, Oxidative Stress, Quinoa

Authors

First Name

Reda

Last Name

Abdel-Razik

MiddleName

Khamis

Affiliation

Pesticides Toxicity to Mammals and Aquatic Organisms, Central Agricultural Pesticide Lab., Agricultural Research Center, Alexandria, Egypt

Email

redarazik216@gmail.com

City

Alexandria

Orcid

0000-0002-0003-744X

First Name

Nadia

Last Name

Hamed

MiddleName

Ali

Affiliation

Researcher Pesticides Toxicity to Mammals and Aquatic Organisms, Central Agricultural Pesticide Lab., Agricultural Research Center, Alexandria, Egypt

Email

nadia010560@gmail.com

City

الاسکندرية

Orcid

-

Volume

42

Article Issue

4

Related Issue

28123

Issue Date

2021-10-01

Receive Date

2021-09-20

Publish Date

2021-12-30

Page Start

809

Page End

822

Print ISSN

1110-0176

Online ISSN

2536-9784

Article File

ASEJAIQJSAE_Volume 42_Issue 4_Pages 809-822.pdf

PDF . 374.0kB

Link

https://asejaiqjsae.journals.ekb.eg/article_201175.html

Detail API

https://asejaiqjsae.journals.ekb.eg/service?article_code=201175

Order

3

Type

Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

Chlorfenapyr Induce Oxidative Phosphorylation Deficiency in Exposed Rat and the Quinoa Effective Role

Details

Type

Article

Created At

22 Jan 2023