Beta
ManageSearchChatDiscover
169608

Synthesis, Herbicidal Activity and Molecular Docking of some New Chloroacetamide Derivatives

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Plant pest management

Abstract

Four novel chloroacetamide derivatives were synthesized 2-Chloro-N-(2,4-dichlorobenzyl)-N-(3,5-dimethylphenyl)acetamide (2), 2-Chloro-N-(2,4-dichlorobenzyl)-N-(2,5-dichlorophenyl)acetamide (4), 2-Chloro-N-cinnamyl-N-(4-sulfamoylphenyl)acetamide (6) and 2-chloro-N-(2,5-dichlorophenyl)-N-(2-hydroxybenzyl)acetamide (8) and evaluated as herbicidal agents against two weed species; Anagallis arvensis as broad leaf weed and Lolium temulentum as a narrow weed in comparison with acetochlor as a standard herbicide. Mass spectra, 1H-NMR and 13C-NMR had approved the chemical structures of the synthesized compounds. Depending on the estimation of chlorophyll content, compounds 4 and 2 have been characterized as the most potent, against tested weeds and had EC50 values lower than acetochlor as standard herbicide. In addition, the molecular docking to the active sites of Very Long Chain Fatty Acid Synthase (VLCFAs) as a target enzyme shown that the derivatives gave minimal binding energy and acceptable affinity for the active site.
 

DOI

10.21608/asejaiqjsae.2021.169608

Keywords

Synthesis, Chloroacetamide derivatives, Herbicidal activity, docking, VLCFAs

Authors

First Name

Saad R.

Last Name

El-Zemity

MiddleName

-

Affiliation

Department of Pesticide Chemistry and Technology, Faculty of Agriculture, 21545-El-Shatby, Alexandria University, Alexandria, Egypt. Phone: 002039575269; Fax: 002035972780; E-mail: Saad_elzemity@yahoo.com

Email

saad_elzemity@yahoo.com

City

-

Orcid

-

First Name

Kareem E.

Last Name

E. Esmaiel

MiddleName

-

Affiliation

Pesticide Chemistry and Technology Department, Faculty of Agriculture, 21545-El-Shatby, Alexandria University, Alexandria, Egypt

Email

perencealkemia@gmail.com

City

-

Orcid

-

First Name

Mohamed E.

Last Name

I. Badawy

MiddleName

-

Affiliation

Pesticide Chemistry and Technology Department, Faculty of Agriculture, 21545-El-Shatby, Alexandria University, Alexandria, Egypt

Email

-

City

-

Orcid

-

Volume

42

Article Issue

2

Related Issue

23719

Issue Date

2021-04-01

Receive Date

2021-03-21

Publish Date

2021-06-30

Page Start

341

Page End

350

Print ISSN

1110-0176

Online ISSN

2536-9784

Article File

ASEJAIQJSAE_Volume 42_Issue 2_Pages 341-350.pdf

PDF . 3.1MB

Link

https://asejaiqjsae.journals.ekb.eg/article_169608.html

Detail API

https://asejaiqjsae.journals.ekb.eg/service?article_code=169608

Order

9

Type

Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

Synthesis, Herbicidal Activity and Molecular Docking of some New Chloroacetamide Derivatives

Details

Type

Article

Created At

22 Jan 2023