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115132

Hepatoprotective Effect of Moringa oleifera Leaves and Seeds Powder on Carbon Tetrachloride Induced Hepatotoxicity in Rats

Article

Last updated: 01 Jan 2025

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Subjects

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Tags

Food Science and technology

Abstract

The main objective of this study was to investigate the effect of supplementing CCL4-exposed male Sprague Dawley albino rats with 10 and 5% leaves and seeds powder of Moringa oleifera Lam (Moringaceae, M. oleifera) respectively  on liver functions. The experiment was carried out on 40 male Albino rats divided into 5 equal groups; 1st group fed on basal diet and kept as a (control-). Rats in the other four groups (n=32) were intoxicated by subcutaneous injection of CCl4 (2ml/kg) twice a week for two consecutive weeks to induce hepatic chronic damage, then those rats were subdivided into: a group that control positive (control+) [2nd group], a group that fed on basal  diet + Moringa oleifera leaves powder 10% [3rd group]; a group that fed on basal diet + Moringa oleifera seeds powder 5% [4th group]; a group that fed on basal diet + silymarin whereas silymarin-treated  was orally administrated with silymarin 50 mg/kg [5th group]. The results showed that the total cholesterol, triglycerides, LDL-C, AST, ALT, and urea levels decreased significantly with treated rats with Moringa oleifera powder, and the best result was belonged to the group of rats that fed on Moringa oleifera leaves 10%. It can be concluded that, supplementation with high percentage of Moringa oleifera exerts a positive impact on the liver functions, lipid profile and other biochemical parameters.

DOI

10.21608/asejaiqjsae.2020.115132

Keywords

Moringa oleifera, antioxidants, biochemical parameters, Rats

Authors

First Name

Suzan A.

Last Name

Abushal

MiddleName

-

Affiliation

Food Science and Nutrition Department, Turabah University College, Taif University Kingdom of Saudi Arabia Ministry of Education Corresponding author: E.mail; S.aboshal@tu.edu.sa E. mail: sozanabushal@yahoo.com

Email

s.aboshal@tu.edu.sa

City

-

Orcid

-

Volume

41

Article Issue

July-September

Related Issue

16340

Issue Date

2020-09-01

Receive Date

2020-08-26

Publish Date

2020-09-30

Page Start

371

Page End

379

Print ISSN

1110-0176

Online ISSN

2536-9784

Article File

ASEJAIQJSAE_Volume 41_Issue July-September_Pages 371-379.pdf

PDF . 510.9kB

Link

https://asejaiqjsae.journals.ekb.eg/article_115132.html

Detail API

https://asejaiqjsae.journals.ekb.eg/service?article_code=115132

Order

6

Type

Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

Hepatoprotective Effect of Moringa oleifera Leaves and Seeds Powder on Carbon Tetrachloride Induced Hepatotoxicity in Rats

Details

Type

Article

Created At

22 Jan 2023