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Toxicological and Biochemical Effects of Four Bioactive Secondary Plant Metabolites Isolated from Simmondsia Chinensis (Link) and Artemisia judaica L. on White Albino Rats

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Last updated: 01 Jan 2025

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Abstract

Four pesticidal botanicals were isolated (two from, Simmondsia chinensisand two fromArtemisia judaica) and identified as simmondsin, simmondsin 2`ferulate, piperitone and trans-ethyl cinnamate, respectively. Oral administration of single doses each of 250 or 500 mg/kg from each compound did not show any signs of toxicity or mortality to male albino rats after two days of treatment. The in vivo effects of these compounds on activities of alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), lactate dehydrogenase (LDH) and creatinine phosphokinase (CPK) in the serum of treated rats and concentrations of testosterone, follicle stimulation hormone (FSH) and triiodothyronine hormone (T3) were evaluated. Simmondsin 2´-ferulate displayed significant decrease in the activity of ALP enzymes at the two tested doses. Simmondsin caused decrease in the activity of the enzymes at 250 mg/kg and increase in the enzymes activity at 500 mg/kg. Piperitone and trans-ethyl cinnamate increased the activity of the enzymes at two tested doses. The tested compounds showed no significant effect on the activity of GGT except for trans-ethyl cinnamate at 500 mg/kg. Simmondsin and simmondsin 2´-ferulate displayed significant decrease in the activity of both LDH and CPK, while piperitone and trans-ethyl cinnamate caused increase in the activity of these enzymes. The tested compounds lowered the concentration of FSH. Simmondsin and simmondsin 2´-ferulate decreased the concentration of T3 and testosterone. Piperitone and trans-ethyl cinnamate increased the concentration of these enzymes.

DOI

10.21608/asejaiqjsae.2008.3196

Keywords

Biochemical effects, simmondsin, simmondsin 2`ferulate, piperitone, trans-ethyl cinnamate, white albino rats, Enzymes, Hormones

Authors

First Name

Moustafa

Last Name

A. Abbassy

MiddleName

-

Affiliation

Department of Pest Control and Environmental Protection, Faculty of Agricultur(Damanhour),Alexandria University,Damanhour, Egypt

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Orcid

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First Name

Samir

Last Name

Abdelazim

MiddleName

-

Affiliation

2Department of Pesticide Chemistry, Faculty of Agriculture, 21545-El-Shatby, Alexandria University, Alexandria, Egypt *Correspondence author. Fax: +20-3-592-0067; Tel.: +20-3-584-7175.

Email

samir1969us@yahoo.com

City

Alexandria

Orcid

-

First Name

Abdel-Salam

Last Name

H. Belal

MiddleName

-

Affiliation

Department of Pest Control and Environmental Protection, Faculty of Agricultur(Damanhour),Alexandria University,Damanhour, Egypt

Email

-

City

-

Orcid

-

First Name

Mona

Last Name

A. Abdel Rasoul

MiddleName

-

Affiliation

Department of Pest Control and Environmental Protection, Faculty of Agricultur(Damanhour),Alexandria University,Damanhour, Egypt

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Volume

29

Article Issue

July-September

Related Issue

557

Issue Date

2008-07-01

Receive Date

2008-09-09

Publish Date

2008-09-30

Page Start

168

Page End

174

Print ISSN

1110-0176

Online ISSN

2536-9784

Article File

ASEJAIQJSAE_Volume 29_Issue July-September_Pages 168-174.pdf

PDF . 396.9kB

Link

https://asejaiqjsae.journals.ekb.eg/article_3196.html

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https://asejaiqjsae.journals.ekb.eg/service?article_code=3196

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8

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Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

Toxicological and Biochemical Effects of Four Bioactive Secondary Plant Metabolites Isolated from Simmondsia Chinensis (Link) and Artemisia judaica L. on White Albino Rats

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Article

Created At

22 Jan 2023