This study was carried out using two soil types of West Delta region, Egypt, at El-Bostan (sandy soil) and North El-Tahrir (sandy loam soil). A two-pot experiment at greenhouse had done through two years 2006 and 2007. The saline irrigation water consists of NaCl, CaCl2 and their mixture (1:1), and added them by 4 doses, (0, 0.1, 0.2, 0.3 and 0.4 M/L). The aim of this study attained the effect of irrigation with saline water on nutrients uptake and production of wheat (Triticum aestivum L.) Sakha8.The obtained results indicated when increase levels of salts in irrigation water, soil pH and EC had positively increased, while the nutrients available in soils or uptake were decrease. Therefore, the plant growth and production of wheat had decreased. The NaCl salt had the highest negative effect on nutrients uptake and production of wheat, and CaCl2 salt had the lowest, while the mixture salts had moderate effect. The suitable level range of NaCl salt was 0.1-0.2M/L and 0.1-0.3M/L for CaCl2 salt, which achieved economic yield of wheat. The critical level of salinity was 0.3M/L of NaCl salt and 0.4M/L of CaCl2 salt, which caused high decrease in yield and damage in soil properties. The grain yields of wheat at rate 0.4M/L of NaCl and CaCl2 was 0.33 and 0.51 Ton/Fed respectively, while it was 1.36 Ton/Fed at the control treatment.