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Deleterious Effect of Abamectin on Rat Brain Mitochondria

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Last updated: 01 Jan 2025

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Plant pest management

Abstract

The neurological damages resulted by abamectin (ABA) poisoning is not completely elucidated, especially in
cellular organelles such as mitochondria. In the present study, the pro-oxidant effect of ABA on rat brain
mitochondria was first investigated. A single oral dose of ABA (3.3mg / Kg body weight; 1/3 LD50) was given to rat and the brain mitochondria were isolated at various times (4, 24 and 336 h) after dosing. Oxidative stress in this organelle was noticed, since it provokes a significant reduction in the activity of adenosine triphosphatase (ATPase) and superoxide dismutase (SOD) and reduced glutathione (GSH) level. In addition, a significant increase in malondialdehyde (MDA) level was observed in neuronal mitochondria, indicating clearly an intense peroxidation within mitochondria. Second, the histochemical evaluation was carried out to estimate the extent of ischemic brain injury as a result of ABA exposure. The average area of
infarct for the neurologically impaired rats was increased in a time-dependent manner. The percentage of surface area of each infarcted section was found to correlate with the severity of the neurologic deficit. The results suggest that ABA-induced neuronal mitochondrial toxicity may be an important contributing factor to brain aging and neurodegenerative diseases.

DOI

10.21608/asejaiqjsae.2015.2964

Keywords

Abamectin toxicity, Antioxidants defence, Brain mitochondria, 2,3,5-triphenyltetrazolium chloride

Authors

First Name

Reda K.

Last Name

Abdel-Razik

MiddleName

-

Affiliation

Dept. of Mammalian and Aquatic Toxicology, Central Agricultural Pesticides Laboratory (CAPL), Agricultural Research Center (ARC), Alexandria, Egypt

Email

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City

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Orcid

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First Name

Nadia A.

Last Name

Hamed

MiddleName

-

Affiliation

Dept. of Mammalian and Aquatic Toxicology, Central Agricultural Pesticides Laboratory (CAPL), Agricultural Research Center (ARC), Alexandria, Egypt

Email

-

City

-

Orcid

-

Volume

36

Article Issue

OCTOBER- DECEMBER

Related Issue

531

Issue Date

2015-12-01

Receive Date

2015-11-03

Publish Date

2015-12-30

Page Start

423

Page End

428

Print ISSN

1110-0176

Online ISSN

2536-9784

Article File

ASEJAIQJSAE_Volume 36_Issue OCTOBER- DECEMBER_Pages 423-428.pdf

PDF . 246.4kB

Link

https://asejaiqjsae.journals.ekb.eg/article_2964.html

Detail API

https://asejaiqjsae.journals.ekb.eg/service?article_code=2964

Order

15

Type

Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

Deleterious Effect of Abamectin on Rat Brain Mitochondria

Details

Type

Article

Created At

22 Jan 2023