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Biochemical Alterations Induced by Abamectin in Albino Rats, Rattus norvegicus

Article

Last updated: 01 Jan 2025

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Tags

Plant pest management

Abstract

Abamectin is a multipurpose pesticide, used as insecticide, nematicide, acaricide and antiparasitic agent in farm animals and pets. This study examined biochemical evaluation of liver and kidney functions as a result of abamectin toxicity in male albino rats. A single sublethal oral dose of 3.3mg Kg-1 body weight (1/3 LD50) was given. Hepatotoxicity was monitored at various times (4, 24 and 336 h) by quantitative analysis of the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) activities, total protein, albumin, total bilrubin, triglycerides and total cholesterol levels. Creatinine and urea were used as the biomarkers of kidney damages.
Results showed that abamectin administration caused no clear interaction on total protein level, while AST, ALT and ALP activities, total bilrubin, triglycerides, cholesterol, creatinine and urea levels were increased. Whereas albumin level showed a significant reduction when compared with control group. 
In conclusion, the results indicated that changes in body and relative organ weights have been used as indicators of adverse effects of abamectin and also the alteration in tested enzymes activity and other parameters can be used as relevant biomarkers for monitoring toxicity due to abamectin exposure in mammals. 

DOI

10.21608/asejaiqjsae.2015.2914

Keywords

Abamectin toxicity, Relative organ weight, biochemical parameters, serum, Rats

Authors

First Name

N. A.

Last Name

Hamed

MiddleName

-

Affiliation

Dept. of Mammalian and Aquatic Toxicology, Central Agricultural Pesticides Laboratory (CAPL), Agricultural Research Center (ARC), Alexandria, Egypt

Email

-

City

-

Orcid

-

First Name

R. K.

Last Name

Abdel-Razik

MiddleName

-

Affiliation

Dept. of Mammalian and Aquatic Toxicology, Central Agricultural Pesticides Laboratory (CAPL), Agricultural Research Center (ARC), Alexandria, Egypt

Email

-

City

-

Orcid

-

Volume

36

Article Issue

JULY-SEPTEMBER

Related Issue

530

Issue Date

2015-09-01

Receive Date

2015-08-26

Publish Date

2015-09-01

Page Start

287

Page End

273

Print ISSN

1110-0176

Online ISSN

2536-9784

Article File

ASEJAIQJSAE_Volume 36_Issue JULY-SEPTEMBER_Pages 287-273.pdf

PDF . 225.6kB

Link

https://asejaiqjsae.journals.ekb.eg/article_2914.html

Detail API

https://asejaiqjsae.journals.ekb.eg/service?article_code=2914

Order

9

Type

Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

Biochemical Alterations Induced by Abamectin in Albino Rats, Rattus norvegicus

Details

Type

Article

Created At

22 Jan 2023