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1892

Lorsban-Induced Changes in Haematological and Some Reproductive Parameters of Male Rats

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Home economics

Abstract

The present study was carried out to investigate the possible toxic effects of different doses of lorsban on blood hematology, testosterone and thyroxin levels, and semen quality of male rats. Lorsban was given to rats by oral route at different doses (5, 10 and 15 mg/kg bw/day) for 6-weeks. The obtained results showed that all three doses of lorsban caused significant changes in the body weight gains and body weight. Relative weights of testes, epididymal and seminal vesicles were significantly (P<0.05) decreased in rats receiving 15 mg/kg only. Also, there was a decrease in mean corpuscular hemoglobin (MCH) and in mean corpuscular volume (MCV) in all experimental animals compared to control ones. While, there were insignificant changes in white blood cells (WBC), hemoglobin (Hb), hematocrit value (Ht), mean cell hemoglobin concentration (MCHC) and red blood cells (RBC) for rats treated with lorsban compared to control group. Meanwhile, it appeared that lorsban caused a rise in thrombocyte (PL) number in individuals treated with the highest dose. Similarly, the highest dose induced significant (p < 0.001) decrease in spermatids number, sperm count and sperm transit rate with an observed impairment of daily sperm production. Such observations were coupled with a reduction in plasma testosterone levels and an increase in plasma free thyroxin (FT4) levels compared to controls. It is, therefore, assumed that treatment with lorsban up to 15 mg/kg bw alters both hematological and reproductive parameters in rats, and subsequently affects fertility.

DOI

10.21608/asejaiqjsae.2007.1892

Keywords

Rats, lorsban, Haematological parameters, semen quality, testosterone, thyroxin

Authors

First Name

Yousef

Last Name

M.I.

MiddleName

-

Affiliation

Department of Environmental Studies, Institute of Graduate Studies & Research, University of Alexandria, Egypt

Email

-

City

-

Orcid

-

First Name

Lotfy

Last Name

T.M.R

MiddleName

-

Affiliation

Department of Home Economics, Faculty of Specific Education, University of Alexandria, Egypt

Email

-

City

-

Orcid

-

Volume

28

Article Issue

OCTOBER- DECEMBER

Related Issue

395

Issue Date

2007-10-01

Receive Date

2007-11-11

Publish Date

2007-10-01

Page Start

216

Page End

223

Print ISSN

1110-0176

Online ISSN

2536-9784

Article File

ASEJAIQJSAE_Volume 28_Issue OCTOBER- DECEMBER_Pages 216-223.pdf

PDF . 581.0kB

Link

https://asejaiqjsae.journals.ekb.eg/article_1892.html

Detail API

https://asejaiqjsae.journals.ekb.eg/service?article_code=1892

Order

8

Type

Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

Lorsban-Induced Changes in Haematological and Some Reproductive Parameters of Male Rats

Details

Type

Article

Created At

22 Jan 2023